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Efek Analgesik Fraksi Etanol dari Ekstrak Etanol Daun Mindi (Melia azedarach L.) pada Mencit Jantan

2. On-line Journal of Universitas Islam Indonesia

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Title Efek Analgesik Fraksi Etanol dari Ekstrak Etanol Daun Mindi (Melia azedarach L.) pada Mencit Jantan
 
Creator Indah Purwantini
Purwantiningsih Purwantiningsih
Oktavia Eka Puspita
 
Description Indonesia has a lot of traditional medicines, which people used long time ago, one of these is mindi (Melia azedarach L.). It have been known that ethanolic extract of mindi leaves has analgesic effect greater than paracetamol at dose 6.44 mg/kgBW and 12.89 mg/kgBW. This research conducted to find out the effectiveness ethanolic fraction of ethanolic extract as an analgesic.  The research was carried out in completely random one way  design, used 35 mice which have been fasted for 24 hours. The mice were divided into 7 groups i.e. negative control, positive control and 5 testing groups (in different doses). Fifteen minutes after injected with the fractions of mindi, the mice were given acetic acid 0.5% intraperitoneally injection. The cumulative writhe reflects were calculated in every 5 minutes for one hour and  were counted the protection percentage. Results showed that the ethanol fractions doses 12,88-103,04 mg/kgBW of mindi leaves have the analgesic effect  in mice and gave protection percentage 30.93-71.61%. The chromatograms of TLC indicated that the fraction contain flavonoids and phenolic compounds.Keywords: ethanol fraction of mindi, analgesic effect, TLC profile
 
Publisher Jurnal Ilmiah Farmasi
 
Contributor
 
Date 2009-05-26
 
Type Peer-reviewed Article
 
Format application/pdf
 
Identifier http://journal.uii.ac.id/index.php/JIF/article/view/470
 
Source Jurnal Ilmiah Farmasi; Vol 4, No 2 (2007)
 
Language en