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Resveratrol Oligomers from Dipterocarpus Hasseltii: Cytotoxic Effect and Chemotaxonomic Significance

2. On-line Journal of Universitas Islam Indonesia

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Title Resveratrol Oligomers from Dipterocarpus Hasseltii: Cytotoxic Effect and Chemotaxonomic Significance
 
Creator Muhtadi Muhtadi
Euis H. Hakim
Yana M. Syah
Lia D. Juliawaty
Jalifah Latip
 
Description Two resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetone extract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the known resveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based on spectroscopic evidence, UV, IR, 1H-NMR, 13C-NMR and determined by comparison with the standard compounds. The cytotoxic activities of these compounds were evaluated against murine leukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 μg/ml, respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shorea and Vatica will also be briefly discussed.Keywords:   Chemotaxonomy, Cytotoxic, Dipterocarpaceae, D. hasseltii,Resveratrol tetramer
 
Publisher Jurnal Ilmiah Farmasi
 
Contributor
 
Date 2009-05-25
 
Type Peer-reviewed Article
 
Format application/pdf
 
Identifier http://journal.uii.ac.id/index.php/JIF/article/view/469
 
Source Jurnal Ilmiah Farmasi; Vol 5, No 1 (2008)
 
Language en